TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 594]

• Applications: WB
• Clone: 376409
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 594

TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human TAPP1
  Pro2-Val404
  Accession # Q9HB21
• Specificity: Detects human TAPP1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 594]

• family A (phosphoinositide bindingspecific) member 1
• PH domain-containing family A member 1
• pleckstrin homology domain containing, family A (phosphoinositide bindingspecific) member 1
• PLEKHA1
• TAPP1

Background

TAPP1, gene name PLEKHA1 (pleckstrin homology family A, member 1) is a 70‑75 kDa cytoplasmic adaptor protein that is membrane-associated after binding of the phosphoinositide, PtdIns(3,4)P2. The 404 aa human TAPP1 shares 76% aa identity with mouse TAPP1. It is expressed most highly in skeletal muscle, spleen, lung, thymus and placenta. TAPP1 interacts with cytoskeletal syntrophins, colocalizing in membrane ruffles following PDGF treatment in transfected NIH‑3T3 cells. TAPP1 and the related TAPP2 appear to play a role in B and T cell activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9HB21()