TAPBPR Antibody (1059329) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 1059329
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

TAPBPR Antibody (1059329) [Alexa Fluor™ Plus 488] Summary

• Specificity: Dectects human TAPBPR in direct ELISA.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TAPBPR Antibody (1059329) [Alexa Fluor™ Plus 488]

• FLJ10143
• TAP binding protein-like
• Tapasin Related Protein/TAPBPR
• Tapasin-like
• TAPASIN-R
• tapasin-related protein
• TAP-binding protein-like
• TAP-binding protein-related protein
• TAPBPL
• TAPBPR
• TAPBP-RTAP binding protein related
• TAPBPRtapasin-like

Background

TAP-binding protein-like (TAPBPL), also known as TAP binding protein-related (TAPBPR) and Tapasin-related protein (TAPASINR) is a transmembrane protein of the Immunoglobulin (Ig) superfamily (1, 2). TAPBPR was originally isolated as a homologue to TAPASIN but more recently was identified as a novel B7 family-related molecule since it shares sequence, structural, and functional similarities to B7 family members (3). Mature human TAPBPR consists of a lumenal domain containing an IgV and IgC domain, a transmembrane domain, and a cytoplasmic tail which lacks an ER retention motif. Within the lumenal domain, mature human TAPBPR shares 70% and 71% amino acid sequence identity with mouse and rat TAPBPR, respectively. Multiple alternatively spliced TAPBPR isoforms are known to exist with unique properties (4).TAPBPR is widely expressed and, similar to TAPASIN, functions as a both a chaperone protein and peptide editor of MHC class I, but in a peptide‑loading complex (PLC) independent manner (5, 6). TAPBPR decreases the rate at which MHC class I molecules mature through the secretory pathway, a role which could be important for peptide selection by MHC class I molecules (7). TAPBPR is also expressed on the surface of T cells and antigen-presenting cells (APCs) and plays an inhibitory role in the proliferation and activation of T cells (4). TAPBPR can be expressed on various cancer cells like leukemia and has the potential to be used in the treatment of autoimmune diseases and transplant rejection, as well as cancer (4).

1. Hermann, C. et al. (2015) Tissue antigens 85(3):155.
2. Teng, M. et al. (2002) European Journal of Immunology 32:1059.
3. Lin, Y. et al. (2021). EMBO Mol Med. 13(5):13404.
4. Porter, K.M. et al. (2014) Immunology 142:289.
5. Margulies, D. et al. (2020) Current Opinion in Immunology 64:71.
6. Boyle, L.H. et al. (2013) PNAS 110:3465.
7. Hermann, C. et al. (2013) Journal of Immunology 191(11):5743.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.