TAPBPR Products

Description

Tapasin Related Protein encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

Bioinformatics

Entrez	213233 Mouse 297602 Rat 55080 Human
Uniprot	NM_018009 Human NP_060479 Human Q9BX59 Human
Product By Gene ID	55080
Alternate Names	FLJ10143 TAP binding protein-like Tapasin-like TAPASIN-R tapasin-related protein TAP-binding protein-like TAP-binding protein-related protein TAPBP-RTAP binding protein related TAPBPRtapasin-like