Synapsin I [p Ser9] Antibody (SN63-04)

Western Blot: Synapsin I [p Ser9] Antibody (SN63-04) [NBP2-67662] - Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- phospho-Synapsin ? (S9) antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: Synapsin I [p Ser9] Antibody (SN63-04) [NBP2-67662] - Analysis of paraffin-embedded rat brain tissue using anti- phospho-Synapsin I (S9) antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: Synapsin I [p Ser9] Antibody (SN63-04) [NBP2-67662] - Analysis of paraffin-embedded mouse brain tissue using anti- phospho-Synapsin I (S9) antibody. Counter stained with hematoxylin.

Product Discontinued

Synapsin I [p Ser9] Antibody (SN63-04) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser9 of Human Synapsin Iaa 1-50 / 705. (SwissProt: P17600 Human; SwissProt: O88935 Mouse; SwissProt: P09951 Rat)
• Modification: p Ser9
• Localization: Cell junction, Golgi apparatus.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: SYN1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Synapsin I [p Ser9] Antibody (SN63-04)

• SYN1
• SYN1a
• SYN1b
• Synapsin 1
• Synapsin I
• synapsin IBrain protein 4.1
• synapsin-1
• SYNI

Background

Synapsin I is a neuron specific protein that is localized to nerve terminals. Synapsin Ia and Synapsin Ib are approximately 80,000 and 77,000 Daltons, respectively, and are collectively referred to as synapsin I. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. It is thought that synapsin I cross-links synaptic vesicles to the cytoskeleton and thereby limits the ability of these synaptic vesicles to move to active zones and fuse with the plasma membrane during exocytosis. In addition to their role in neurotransmission, the synapsins are also thought to play a role in synapse formation. The appearance of synapsin I immunoreactivity correlates precisely with the development of synapses in the CNS. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. The appearance of synapsin I was a precise indicator of synapse formation and that synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SYN1