Substance P Antibody

Immunocytochemistry/Immunofluorescence: Substance P Antibody [NB300-187] - Staining of trigeminal ganglia from P3-P5 rat pups. BMC Neuroscience 2010, 11:32doi:10.1186/1471-2202-11-32

Immunohistochemistry: Substance P Antibody [NB300-187] - Spinal Cord Dorsal Horn (Human).

Immunocytochemistry/Immunofluorescence: Substance P Antibody [NB300-187] - Detection of Substance P in rat spinal cord dorsal horn (red fluorescence). DAPI (blue) was used as counter stain.

Product Discontinued

Substance P Antibody Summary

• Immunogen: A synthetic peptide made between amino acid residues 1-11 of rat Substance P [CRPKPQQFFGLM].
• Isotype: IgG
• Clonality: Polyclonal
• Host: Guinea Pig
• Gene: TAC1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:50-1:100

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for Substance P Antibody

• neurokinin 1
• neurokinin 2
• neurokinin A
• Neurokinin-1
• neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
• neuropeptide gamma
• neuropeptide K
• NK2
• NKA
• NKNAneurokinin alpha
• NPK
• PPT
• protachykinin-1
• substance K
• Substance P
• TAC1
• TAC2neuromedin L
• tachykinin 2
• tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
• tachykinin, precursor 1

Background

The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Substance P Antibody (NB300-187)(8)

Publications using NB300-187

• Andreska T, Lüningschrör P, Wolf D et al. DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons Cell reports 2023-05-29 [PMID: 37252844] (IHC, Rat)
• Schrodl F, Kaser-Eichberger A, Trost A et al. Alarin in cranial autonomic ganglia of human and rat. Exp. Eye Res. 2014-12-09 [PMID: 25497346] (IF/IHC, Rat)
• Chen W, McRoberts J A, Marvizon J C G. mu-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience. 2014-05-16 [PMID: 24583035] (Rat)
• Lyu RM, Huang XF, Zhang Y et al. Phoenixin: a novel peptide in rodent sensory ganglia. Neuroscience 2013-07-30 [PMID: 23912037] (IF/IHC, ICC/IF, Mouse)
• Beyer J, Jabari S, Rau TT et al. Substance P- and choline acetyltransferase immunoreactivities in somatostatin-containing, human submucosal neurons. Histochem Cell Biol 2013-01-30 [PMID: 23361835] (IF/IHC, ICC/IF, Human)
• Kavut AB, Kalpakl?oglu F, Atasoy P. Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis. Int Arch Allergy Immunol 2012-09-25 [PMID: 23018649]
• Ditting T, Freisinger W, Siegel K et al. Tonic postganglionic sympathetic inhibition induced by afferent renal nerves? Hypertension 2012-02-01 [PMID: 22215714] (ICC/IF, Rat)
• Brehmer A, Lindig TM, Schrodl F et al. Morphology of enkephalin-immunoreactive myenteric neurons in the human gut. Histochem Cell Biol 2005-02-01 [PMID: 15776249]

Bioinformatics

• Gene Symbol: TAC1
• Entrez:
  • 6863(Human)
  • 21333(Mouse)
  • 24806(Rat)
• Uniprot:
  • P06767(Rat)