Stargazin Antibody (S245-36) [Alexa Fluor® 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clone: S245-36
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Stargazin Antibody (S245-36) [Alexa Fluor® 594] Summary

• Immunogen: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
• Localization: Membrane
• Specificity: Detects approx 35-55kDa. Does not cross-react with TARPGamma3.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CACNG2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Stargazin Antibody (S245-36) [Alexa Fluor® 594]

• calcium channel, voltage-dependent, gamma subunit 2
• FLJ41437
• MGC138502
• MGC138504
• Neuronal voltage-gated calcium channel gamma-2 subunit
• stargazin
• voltage-dependent calcium channel gamma-2 subunit

Background

Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002). Stargazin mutant mice are utilized as a model for absence epilepsy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CACNG2