Stargazin Antibody (S245-1)

Product Discontinued

Stargazin Antibody (S245-1) Summary

• Immunogen: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
• Localization: Membrane
• Specificity: Detects approx 36kDa. Does not cross-react with TARPGamma3, TARPGamma4 and TARPGamma8.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CACNG2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: 1 ug/ml of TARP Gamma2/Stargazin Antibody was sufficient for detection of TARP Gamma2/ Stargazin in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary Antibody.

Reactivity Notes

Based on homology, It's predicted to detect Human and Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 50% Glycerol
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein G purified

Alternate Names for Stargazin Antibody (S245-1)

• calcium channel, voltage-dependent, gamma subunit 2
• FLJ41437
• MGC138502
• MGC138504
• Neuronal voltage-gated calcium channel gamma-2 subunit
• stargazin
• voltage-dependent calcium channel gamma-2 subunit

Background

Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002). Stargazin mutant mice are utilized as a model for absence epilepsy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CACNG2
• Uniprot:
  • Q71RJ2(Rat)