SLC35D1 Antibody

Product Discontinued

SLC35D1 Antibody Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human Slc35D1. The immunogen is located within the first 50 amino acids of Slc35D1.
• Specificity: This antibody is predicted to not cross-react with the highly homologous Slc35D2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC35D1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: Slc35D1 antibody can be used for detection of Slc35D1 by Western blot at 1 - 2 mg/ml.

Reactivity Notes

Expected species cross reactivity based on sequence homology: Bovine (88%), Porcine (81%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for SLC35D1 Antibody

• KIAA0260MGC138236
• solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dualtransporter), member D1
• Solute carrier family 35 member D1
• UDP-galactose transporter-related protein 7
• UDP-GlcA/UDP-GalNAc transporter
• UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
• UGTrel7
• UGTREL7UDP-galactose transporter-related 7

Background

The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia. This antibody is predicted to not cross-react with the highly homologous Slc35D2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC35D1
• Uniprot:
  • NP_055954(Human)