Slap Antibody

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Immunohistochemistry-Paraffin: Slap Antibody [NBP2-24696] - Formalin-fixed, paraffin-embedded human kidney stained with SLAP antibody at 15 ug/ml. Staining of formalin-fixed tissues is enhanced by boiling tissue ...read more

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Slap Antibody Summary

Immunogen
A portion of amino acids 175-225 of human SLAP was used as the immunogen for the antibody.
Predicted Species
Chimpanzee (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLA
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5-15 ug/ml
Publications
Read Publication using
NBP2-24696 in the following applications:

Reactivity Notes

The SLAP amino acid sequence used as immunogen for the antibody is 100% homologous in human (isoforms a, b and c) and chimpanzee, 83% homologous in mouse and 78% homologous in rat and bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for Slap Antibody

  • hSLAP
  • SLA1
  • SLAP
  • SLAP1
  • SLAP-1
  • Src-like-adapter protein 1
  • Src-like-adapter
  • Src-like-adaptor

Background

SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas but is high in lung and fetal brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Slap Antibody (NBP2-24696)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.


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IHC-P
(1)
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Human
(1)
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Bioinformatics

Gene Symbol SLA
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