SHANK1 Antibody (N22/21) [mFluor Violet 450 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, IHC, MA
• Clone: N22/21
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 450 SE

SHANK1 Antibody (N22/21) [mFluor Violet 450 SE] Summary

• Immunogen: Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
• Localization: Cytoplasm , Cell Junction , Synapse , Postsynaptic Cell Membrane , Postsynaptic Density
• Specificity: Detects approx 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SHANK1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Microarray
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SHANK1 Antibody (N22/21) [mFluor Violet 450 SE]

• SH3 and multiple ankyrin repeat domains 1
• SH3 and multiple ankyrin repeat domains protein 1
• Shank1
• Somatostatin receptor-interacting protein
• SSTR-interacting protein
• SSTRIPSPANK-1
• synamon

Background

Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SHANK1