Serpin B8/Proteinase Inhibitor 8 Antibody (423023) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 423023
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Serpin B8/Proteinase Inhibitor 8 Antibody (423023) [Alexa Fluor® 594] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf21-derived recombinant human Serpin B8/Proteinase Inhibitor 8
  Asp2-Pro374
  Accession # P50452
• Specificity: Detects human Serpin B8/Proteinase Inhibitor 8 in direct ELISAs. In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse (rm) Serpin B8 is observed. No cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A6, A9, A11, A12,
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin B8/Proteinase Inhibitor 8 Antibody (423023) [Alexa Fluor® 594]

• CAP2
• CAP-2
• CAP2clade B (ovalbumin), member 8
• Cytoplasmic antiproteinase 2
• NK10
• Peptidase inhibitor 8
• PI8
• PI-8
• protease inhibitor 8 (ovalbumin type)
• Serpin B8
• serpin peptidase inhibitor, clade B (ovalbumin), member 8

Background

Serpin B8 (serine proteinase inhibitor-clade B #8; also PI8) is a 42‑45 kDa, cytoplasmic and secreted member of the ovalbumin (clade B)-subfamily, Serpin superfamily of protease inhibitors. It is produced by multiple cell types and shows inhibitory activity towards furin and other proteinases such as chymotrypsin. Human Serpin B8 is 374 amino acids (aa) in length. Although it has no signal sequence, it is released by platelets. The active inhibitor site lies between Arg336 and Arg342. One potential isoform shows a 2 aa substitution for the C-terminal 134 amino acids. Full length human Serpin B8 shares 78% and 83% aa identity with mouse and canine Serpin B8, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.