SERCA3 ATPase Antibody

Product Discontinued

SERCA3 ATPase Antibody Summary

• Immunogen: Synthetic Peptide: V(29) T D A R E R Y G P N(39).
• Specificity: Detects sarcoplasmic or endoplasmic reticulum calcium ATPase 3 (SERC A3) human and rat recombinant protein. This does not detect other SERCA isoforms.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ATP2A3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1:500
• Application Notes: WB: Detects an approx. 97 kDa protein representing recombinant human SERCA 3 expressed in E. coli.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SERCA3 ATPase Antibody

• adenosine triphosphatase, calcium
• ATP2A3
• ATPase, Ca(2+)-transporting, ubiquitous
• ATPase, Ca++ transporting, ubiquitous
• Calcium pump 3
• EC 3.6.3
• EC 3.6.3.8
• sarco/endoplasmic reticulum Ca2+ ATPase
• sarco/endoplasmic reticulum Ca2+ -ATPase
• sarcoplasmic/endoplasmic reticulum calcium ATPase 3
• SERCA3 ATPase
• SERCA3
• SERCA3calcium-translocating P-type ATPase
• SR Ca(2+)-ATPase 3

Background

ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA 2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA 2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA 2b isoform expressed in all cell types. SERCA 3 has been found to co-express with SERCA 2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ATP2A3
• Entrez:
  • 25391(Rat)