SERCA3 ATPase Antibody

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

SERCA3 ATPase Antibody Summary

Immunogen
Synthetic Peptide: V(29) T D A R E R Y G P N(39).
Specificity
Detects sarcoplasmic or endoplasmic reticulum calcium ATPase 3 (SERC A3) human and rat recombinant protein. This does not detect other SERCA isoforms.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ATP2A3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
Application Notes
WB: Detects an approx. 97 kDa protein representing recombinant human SERCA 3 expressed in E. coli.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS containing 1 mg/ml BSA and 0.05% sodium azide.
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SERCA3 ATPase Antibody

  • adenosine triphosphatase, calcium
  • ATPase, Ca(2+)-transporting, ubiquitous
  • ATPase, Ca++ transporting, ubiquitous
  • Calcium pump 3
  • EC 3.6.3
  • EC 3.6.3.8
  • sarco/endoplasmic reticulum Ca2+ ATPase
  • sarco/endoplasmic reticulum Ca2+ -ATPase
  • sarcoplasmic/endoplasmic reticulum calcium ATPase 3
  • SERCA3calcium-translocating P-type ATPase
  • SR Ca(2+)-ATPase 3

Background

ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA 2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA 2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA 2b isoform expressed in all cell types. SERCA 3 has been found to co-express with SERCA 2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on SERCA3 ATPase.

Mending a Broken Heart: New SERCA2 Gene Therapy Fights Heart Disease
While many of the proteins on our antibody database are studied in relation to their expression in diseases; others become therapies in their own right. This is the case with SERCA2 (Sarcoplasmic reticulum Calcium-ATPase 2 pump), which recently hit th...  Read full blog post.

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Bioinformatics

Gene Symbol ATP2A3
Entrez