SEC13 Antibody (1280C) [Alexa Fluor® 532]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 1280C
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 532

SEC13 Antibody (1280C) [Alexa Fluor® 532] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: E. coli-derived recombinant human SEC13
  Gly123-Gln322
  Accession # P55735
• Specificity: Detects human SEC13 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SEC13 Antibody (1280C) [Alexa Fluor® 532]

• D3S1231E
• D3S1231ESEC13L1npp-20
• Npp-20
• protein SEC13 homolog
• SEC13 (S. cerevisiae)-like 1
• SEC13 homolog (S. cerevisiae)
• SEC13
• SEC13L1
• SEC13-like 1 isoform
• SEC13-like protein 1
• SEC13R
• SEC13-related protein
• SEC13RSEC13-like 1 (S. cerevisiae)

Background

Sec13 is a ubiquitously expressed protein which participates in the formation of vesicles in the COPII complex with Sec23p^.Sec24p, Sar1p and Sec31. The COPII vesicle budding complex was first described in the yeast system and was shown to provide coat proteins in the early secretory pathway. Sec13 is recruited to endoplasmic reticulum (ER) membranes where it forms a three dimensional cuboctahedron cage lattice structure by association with Sec31. This vesicular structure is necessary for ER-Golgi transport.  Presenillin-1, which is implicated in early-onset Alzheimer's disease has been shown to interact with Sec13 vesicles.  Additionally, Sec13 has been shown to be a component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC), and the GATOR2 sub-complex of the GATOR complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.