SDHD Antibody (3F4)

Product Discontinued

SDHD Antibody (3F4) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: SDHD (AAH09574, 57 a.a. - 159 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
• Specificity: SDHD (3F4)
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SDHD
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for SDHD Antibody (3F4)

• CBT1
• CII-4
• cybS
• PGL
• PGL1
• QPs3
• SDH4
• succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
• Succinate dehydrogenase complex subunit D
• succinate dehydrogenase complex, subunit D, integral membrane protein
• succinate dehydrogenase ubiquinone cytochrome B small subunit
• Succinate-ubiquinone oxidoreductase cytochrome b small subunit
• Succinate-ubiquinone reductase membrane anchor subunit

Background

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SDHD Antibody (H00006392-M04)(1)

Publication using H00006392-M04

• Xekouki P, Pacak K, Almeida M et al. Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?. J Clin Endocrinol Metab 2012-03-01 [PMID: 22170724]

Bioinformatics

• Gene Symbol: SDHD
• Entrez:
  • 6392(Human)
• OMIM:
  • 114900(Human)
• Uniprot:
  • AAH09574(Human)