Scn1a Antibody (RB57630) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: WB, Flow
• Clone: RB57630
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Janelia Fluor 549

Scn1a Antibody (RB57630) [Janelia Fluor® 549] Summary

• Immunogen: This SCN1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 481-515 amino acids from the Central region of human SCN1A.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SCN1A
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Scn1a Antibody (RB57630) [Janelia Fluor® 549]

• brain I alpha subunit
• DEE6
• DEE6A
• DEE6B
• DRVT
• EIEE6
• FEB3
• FEB3A
• FHM3
• GEFSP2
• HBSCI
• NAC1
• Nav1.1
• SCN1
• SMEI
• sodium channel, voltage-gated, type I, alpha polypeptide
• sodium channel, voltage-gated, type I, alpha subunit

Background

Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript. [provided by RefSeq, Oct 2015]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SCN1A