Recombinant Mouse IFN-alpha A Protein

• Reactivity: Mu

Recombinant Mouse IFN-alpha A Protein Summary

• Additional Information: A New rmIFN-alpha A is Available! It is mammalian cell derived, has lower endotoxin specifications, is made in-house, and is priced competitively!
• Accession #: NP_996753
• Protein/Peptide Type: Recombinant Proteins

Applications/Dilutions

Publications

Read Publications using 12100-1 in the following applications: Bioassay 19 publications Cell Culture 1 publication Immunoprecipitation 1 publication In Vivo 4 publications

Packaging, Storage & Formulations

• Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IFN-alpha A Protein

• alpha-2a interferon
• Ifa2
• IFNA
• IFNA2
• IFNA2a
• IFNA2b
• IFNA2c
• IFNAA
• IFNalpha 2
• IFN-alpha 2
• IFN-alpha-2
• IFN-alphaA
• INFA2
• interferon alpha 2b
• interferon alpha A
• interferon alpha-2
• Interferon alpha-A
• interferon, alpha 2
• LeIF A
• MGC125764
• MGC125765

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Publications for IFN-alpha 2 (12100-1)(25)

Publications using 12100-1

• Gervais, A;Le Floc'h, C;Le Voyer, T;Bizien, L;Bohlen, J;Celmeli, F;Al Qureshah, F;Masson, C;Rosain, J;Chbihi, M;Lévy, R;Castagnoli, R;Rothenbuhler, A;Jouanguy, E;Zhang, Q;Zhang, SY;Béziat, V;Bustamante, J;Puel, A;Bastard, P;Casanova, JL; A sensitive assay for measuring whole-blood responses to type I IFNs Proceedings of the National Academy of Sciences of the United States of America 2024-10-01 [PMID: 39312669] (Bioassay, Human)
• L Yang, S Chen, Q Zhao, C Pan, L Peng, Y Han, L Li, J Ruan, J Xia, H Yang, F Xu, G Cheng Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription Cell Reports, 2022-01-25;38(4):110302. 2022-01-25 [PMID: 35081346] (Bioassay, Mouse)
• JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease Nature, 2020-09-02;0(0):. 2020-09-02 [PMID: 32879487] (Bioassay, Mouse)
• C Ge, IR Monk, A Pizzolla, N Wang, JG Bedford, TP Stinear, GP Westall, LM Wakim Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment Cell Rep, 2019-12-24;29(13):4236-4244.e3. 2019-12-24 [PMID: 31875535] (Cell Culture, Mouse)
• K Haruwaka, A Ikegami, Y Tachibana, N Ohno, H Konishi, A Hashimoto, M Matsumoto, D Kato, R Ono, H Kiyama, AJ Moorhouse, J Nabekura, H Wake Dual microglia effects on blood brain barrier permeability induced by systemic inflammation Nat Commun, 2019-12-20;10(1):5816. 2019-12-20 [PMID: 31862977] (In Vivo, Mouse)
• Y Zhang, F Thery, NC Wu, EK Luhmann, O Dussurget, M Foecke, C Bredow, D Jiménez-Fe, K Leandro, A Beling, KP Knobeloch, F Impens, P Cossart, L Radoshevic The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection Nat Commun, 2019-11-26;10(1):5383. 2019-11-26 [PMID: 31772204] (Immunoprecipitation, Mouse)
• ST Gal-Oz, B Maier, H Yoshida, K Seddu, N Elbaz, C Czysz, O Zuk, BE Stranger, H Ner-Gaon, T Shay ImmGen report: sexual dimorphism in the immune system transcriptome Nat Commun, 2019-09-20;10(1):4295. 2019-09-20 [PMID: 31541153] (In Vivo, Mouse)
• W Li, G Feng, JM Gauthier, I Lokshina, R Higashikub, S Evans, X Liu, A Hassan, S Tanaka, M Cicka, HM Hsiao, D Ruiz-Perez, A Bredemeyer, RW Gross, DL Mann, YY Tyurina, AE Gelman, VE Kagan, A Linkermann, KJ Lavine, D Kreisel Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation J. Clin. Invest., 2019-02-26;130(0):. 2019-02-26 [PMID: 30830879] (In Vivo, Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Bioassay, Mouse)
• Network pharmacology of JAK inhibitors Proc Natl Acad Sci USA, 2016-08-11;0(0):. 2016-08-11 [PMID: 27516546] (Bioassay, Mouse)
• Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence PLoS ONE, 2016-05-19;11(5):e0155947. 2016-05-19 [PMID: 27196057] (In Vivo, Mouse)
• P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells Oncogene, 2016-04-25;0(0):. 2016-04-25 [PMID: 27109100] (Bioassay, Mouse)
• Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015-09-28;195(9):4446-55. 2015-09-28 [PMID: 26416280] (Bioassay, Mouse)
• Kuriakose T, Tripp R, Watford W Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus. PLoS Pathog, 2015-08-04;11(8):e1005038. 2015-08-04 [PMID: 26241898] (Bioassay, Mouse)
• Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity. Mol Cancer, 2014-05-31;13(0):132. 2014-05-31 [PMID: 24884733] (Bioassay, Mouse)
• Yao H, Goldman D, Nechiporuk T, Kawane S, McWeeney S, Tyner J, Fan G, Kerenyi M, Orkin S, Fleming W, Mandel G Corepressor Rcor1 is essential for murine erythropoiesis. Blood, 2014-03-20;123(20):3175-84. 2014-03-20 [PMID: 24652990] (Bioassay, Mouse)
• Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol, 2014-03-09;15(4):333-42. 2014-03-09 [PMID: 24608040] (Bioassay, Mouse)
• Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol, 2014-03-06;96(1):123-31. 2014-03-06 [PMID: 24604832] (Bioassay, Mouse)
• Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci U S A, 2014-01-27;111(8):3068-73. 2014-01-27 [PMID: 24469805] (Bioassay, Mouse)
• Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A The exonuclease Trex1 restrains macrophage proinflammatory activation. J Immunol, 2013-11-11;191(12):6128-35. 2013-11-11 [PMID: 24218451] (Bioassay, Mouse)
• Kerenyi , Marc A, Shao , Zhen, Hsu , Yu-Jung, Guo , Guoji, Luc , Sidinh, O'Brien , Kassandr, Fujiwara , Yuko, Peng , Cong, Nguyen , Minh, Orkin , Stuart H Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife, 2013-06-18;2(0):e00633. 2013-06-18 [PMID: 23795291] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R IFN-gamma down-regulates Secretoglobin 3A1 gene expression. Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8. 2009-01-09 [PMID: 19135978] (Bioassay, Mouse)
• Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)
• Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J. Virol., 2005-10-01;79(20):12828-39. 2005-10-01 [PMID: 16188985] (Bioassay, Mouse)

Bioinformatics

• Uniprot:
  • NP_996753()