Recombinant Mouse IFN-alpha A Protein Summary
Packaging, Storage & Formulations
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Recombinant Mouse IFN-alpha A Protein
IFNA IFNA2 IFNA2b IFNalpha IFN-alpha IFN-alphaA INFA2 interferon alpha 2 Background
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
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Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
Species: Hu, Mu, Rt, Fi, Ze
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Applications: WB, ELISA
Applications: WB, Simple Western, CyTOF-ready, ICC, ICFlow, KO
Applications: WB, ICC
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IP
Applications: WB, Simple Western, ELISA, ICC/IF, IHC, IHC-P, IP
Publications for IFN-alpha (12100-1)(17)
We have publications tested in 1 confirmed species: Mouse.
We have publications tested in 2 applications: Bioassay, In Vivo.
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Show All 17 Publications.
Publications using 12100-1
MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017;0(0):. 2017 [PMID: 28576981] (Bioassay, Mouse) Bioassay
Network pharmacology of JAK inhibitors Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27516546] (Bioassay, Mouse) Bioassay
Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence PLoS ONE, 2016;11(5):e0155947. 2016 [PMID: 27196057] (In Vivo, Mouse) In Vivo
P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells Oncogene, 2016;0(0):. 2016 [PMID: 27109100] (Bioassay, Mouse) Bioassay
Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015;195(9):4446-55. 2015 [PMID: 26416280] (Bioassay, Mouse) Bioassay
Kuriakose T, Tripp R, Watford W Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus. PLoS Pathog, 2015;11(8):e1005038. 2015 [PMID: 26241898] (Bioassay, Mouse) Bioassay
Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity. Mol Cancer, 2014;13(0):132. 2014 [PMID: 24884733] (Bioassay, Mouse) Bioassay
Yao H, Goldman D, Nechiporuk T, Kawane S, McWeeney S, Tyner J, Fan G, Kerenyi M, Orkin S, Fleming W, Mandel G Corepressor Rcor1 is essential for murine erythropoiesis. Blood, 2014;123(20):3175-84. 2014 [PMID: 24652990] (Bioassay, Mouse) Bioassay
Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol, 2014;15(4):333-42. 2014 [PMID: 24608040] (Bioassay, Mouse) Bioassay
Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol, 2014;96(1):123-31. 2014 [PMID: 24604832] (Bioassay, Mouse) Bioassay
Show All 17 Publications.
IFN-alpha (12100-1) (0)
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