Recombinant Mouse IFN-alpha A Protein

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Product Details

Summary
Reactivity MuSpecies Glossary

Order Details

Recombinant Mouse IFN-alpha A Protein Summary

Accession #
Protein/Peptide Type
Recombinant Proteins

Applications/Dilutions

Publications
Read Publications using
12100-1 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IFN-alpha A Protein

  • IFNA
  • IFNA2
  • IFNA2b
  • IFNalpha
  • IFN-alpha
  • IFN-alphaA
  • INFA2
  • interferon alpha 2

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

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Publications for IFN-alpha (12100-1)(17)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.


Filter By Application
Bioassay
(16)
In Vivo
(1)
All Applications
Filter By Species
Mouse
(17)
All Species
Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using 12100-1 Applications Species
MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017;0(0):. 2017 [PMID: 28576981] (Bioassay, Mouse) Bioassay Mouse
Network pharmacology of JAK inhibitors Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27516546] (Bioassay, Mouse) Bioassay Mouse
Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence PLoS ONE, 2016;11(5):e0155947. 2016 [PMID: 27196057] (In Vivo, Mouse) In Vivo Mouse
P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells Oncogene, 2016;0(0):. 2016 [PMID: 27109100] (Bioassay, Mouse) Bioassay Mouse
Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015;195(9):4446-55. 2015 [PMID: 26416280] (Bioassay, Mouse) Bioassay Mouse
Kuriakose T, Tripp R, Watford W Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus. PLoS Pathog, 2015;11(8):e1005038. 2015 [PMID: 26241898] (Bioassay, Mouse) Bioassay Mouse
Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity. Mol Cancer, 2014;13(0):132. 2014 [PMID: 24884733] (Bioassay, Mouse) Bioassay Mouse
Yao H, Goldman D, Nechiporuk T, Kawane S, McWeeney S, Tyner J, Fan G, Kerenyi M, Orkin S, Fleming W, Mandel G Corepressor Rcor1 is essential for murine erythropoiesis. Blood, 2014;123(20):3175-84. 2014 [PMID: 24652990] (Bioassay, Mouse) Bioassay Mouse
Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R A role for the ITAM signaling module in specifying cytokine-receptor functions. Nat Immunol, 2014;15(4):333-42. 2014 [PMID: 24608040] (Bioassay, Mouse) Bioassay Mouse
Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol, 2014;96(1):123-31. 2014 [PMID: 24604832] (Bioassay, Mouse) Bioassay Mouse
Show All 17 Publications.

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Additional Array Products

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Blogs on IFN-alpha.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...  Read full blog post.

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