Recombinant Mouse CL-K1/COLEC11 Protein, CF

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Mouse CL-K1/COLEC11 Protein, CF Summary

Details of Functionality
Measured by its ability to bind alpha -L-Fucose. Keshi, H. et al. (2006) Microbiol. Immunol. 50(12):1001.
Source
Mouse myeloma cell line, NS0-derived mouse CL-K1/COLEC11 protein
Gln27-Leu272, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
No results obtained: Gln27 predicted
Protein/Peptide Type
Recombinant Proteins
Gene
Colec11
Purity
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
33-38 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CL-K1/COLEC11 Protein, CF

  • CDC28/CDC2-like kinase
  • CDC-like kinase 1CLKEC 2.7.12.1
  • CLK/STY
  • CLK1
  • CL-K1
  • COLEC11
  • dual specificity protein kinase CLK1
  • protein tyrosine kinase STY
  • STY

Background

Collectins constitute a family of C-type lectins that recognize molecular patterns expressed on pathogens. Members of this glycoprotein family contain a N-terminal domain, a collagen-like domain, a neck region, and a C-terminal carbohydrate recognition domain (CRD). Collectins are typically secreted molecules, although CL-P1 is membrane bound and CL-L1 is found in the cytoplasm (1 - 3). Collectin kidney 1 (CL-K1), also known as collectin subfamily member 11 (COLEC11), is a 37 kDa collectin that circulates in the serum (4, 5). It associates into disulfide-linked oligomers and preferentially interacts with fucose residues in a calcium-dependent manner (4). Mature mouse CL-K1 shares 94% and 98% amino acid sequence identity with human and rat CL-K1, respectively. Within the CRD, mouse CL-K1 shares 52% aa sequence identity with CL-L1 and 23% - 32% aa sequence identity with collectins CL-P1, MBL, SP-A, and SP-D.

  1. Gupta, G. and A. Surolia (2007) Bioessays 29:452.
  2. van de Wetering, J.K. et al. (2004) Eur. J. Biochem. 271:1229.
  3. Holmskov, U. et al. (2003) Annu. Rev. Immunol. 21:547.
  4. Keshi, H. et al. (2006) Microbiol. Immunol. 50:1001.
  5. Accession # NP_082142.

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Bioinformatics

Gene Symbol Colec11
Entrez
Uniprot