Recombinant Human IL-29/IFN-lambda 1 Protein, CF


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Reactivity HuSpecies Glossary
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Recombinant Human IL-29/IFN-lambda 1 Protein, CF Summary

Details of Functionality
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al. (2003) Nat. Immunol. 4:63. The ED50 for this effect is 1-5 ng/mL.
Mouse myeloma cell line, NS0-derived human IL-29/IFN-lambda 1 protein
Gly20-Thr200, with a C-terminal 10-His tag
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
21.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
26-35 kDa, reducing conditions
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1598-IL/CF in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-29/IFN-lambda 1 Protein, CF

  • cytokine Zcyto21
  • IFNL1
  • IFN-lambda 1
  • IFN-lambda-1
  • IL29
  • IL-29
  • interferon lambda-1
  • interferon, lambda 1
  • interleukin 29 (interferon, lambda 1)
  • interleukin-29
  • ZCYTO21


IL-28A, IL-28B, and IL-29, also named interferon-lambda 2 (IFN-lambda 2), IFN-lambda 3, and IFN-lambda 1, respectively, are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity) (1-3). The genes encoding these three cytokines are localized to chromosome 19 and each is composed of multiple exons. The exon organization of these genes is also found in the IL-10 family genes but is distinct from the type I IFNs, which are encoded within a single exon, The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor  beta (IL-10 R beta ) and a novel IL-28 receptor  alpha (IL‑28 R alpha, also known as IFN-lambda R1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation. The phosphorylated STAT1 and STAT2 complex with IFN-regulatory factor 9 (IRF-9) to form the IFN-stimulated regulatory factor 3 (ISGF-3) transcription factor complex that is translocated to the nucleus. ISGF-3 binds to the IFN-stimulated response element (ISRE) present in the regulatory region of the target genes. Human IL-29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67% and 69% aa sequence identity with human IL-28A and IL-28B, respectively.
  1. Vilcek, J. (2003) Nature Immunol. 4:8.
  2. Sheppard, P. et al. (2003) Nature Immunol. 4:63.
  3. Kotenko, S.V. et al. (2003) Nature Immunol. 4:69.

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Publications for IL-29/IFN-lambda 1 (1598-IL/CF)(31)

We have publications tested in 2 confirmed species: Human, Primate - Chlorocebus aethiops (African Green Monkey).

We have publications tested in 5 applications: Bioassay, Cell Culture, Control, ELISA (Standard), Stimulation.

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Primate - Chlorocebus aethiops (African Green Monkey)
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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using 1598-IL/CF Applications Species
M Syedbasha, F Bonfiglio, J Linnik, C Stuehler, D Wüthrich, A Egli Interferon-&amp;lambda Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway Cell Rep, 2020;33(1):108211. 2020 [PMID: 33027651] (Bioassay, Human) Bioassay Human
CJ Stairiker, M van Meurs, LG Leon, AA Brouwers-H, L Rijsbergen, YM Mueller, PD Katsikis Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells PLoS ONE, 2020;15(7):e0236195. 2020 [PMID: 32678841] (Bioassay, Human) Bioassay Human
AM Kell, EA Hemann, JB Turnbull, M Gale RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit�Hantaan orthohantavirus replication PLoS Pathog., 2020;16(4):e1008483. 2020 [PMID: 32330200] (Cell Culture, Human) Cell Culture Human
JH Chung, SH Hong, N Seo, TS Kim, HJ An, P Lee, EC Shin, HM Kim Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency Cytokine, 2019;125(0):154833. 2019 [PMID: 31479875] (Bioassay, Human) Bioassay Human
C Good, AI Wells, CB Coyne Type III interferon signaling restricts enterovirus 71 infection of goblet cells Sci Adv, 2019;5(3):eaau4255. 2019 [PMID: 30854425] (Bioassay, Human) Bioassay Human
H Xu, SJ Xu, SJ Xie, Y Zhang, JH Yang, WQ Zhang, MN Zheng, H Zhou, LH Qu MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway Elife, 2019;8(0):. 2019 [PMID: 30735121] (Bioassay, Human) Bioassay Human
I Angelidou, A Chrysantho, A Mitsios, S Arelaki, A Arampatzio, K Kambas, D Ritis, V Tsironidou, I Moschos, V Dalla, D Stakos, G Kouklakis, I Mitroulis, K Ritis, P Skendros REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1? Inflammatory Response in Active Ulcerative Colitis J. Immunol., 2018;0(0):. 2018 [PMID: 29712770] (Bioassay, Human) Bioassay Human
A Pierangeli, M Statzu, R Nenna, L Santinelli, L Petrarca, A Frassanito, M Gentile, G Antonelli, F Midulla, C Scagnolari Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity J. Clin. Virol., 2018;102(0):101-109. 2018 [PMID: 29549834] (Stimulation, Human) Stimulation Human
SS Kwek, S Watanabe, KR Chan, EZ Ong, HC Tan, WC Ng, MTX Nguyen, ES Gan, SL Zhang, KWK Chan, JH Tan, OM Sessions, M Manuel, J Pompon, C Chua, S Hazirah, K Tryggvason, SG Vasudevan, EE Ooi A systematic approach to the development of a safe live attenuated Zika vaccine Nat Commun, 2018;9(1):1031. 2018 [PMID: 29531213] (Cell Culture, Primate - Chlorocebus aethiops (African Green Monkey)) Cell Culture Primate - Chlorocebus aethiops (African Green Monkey)
AA Obajemu, N Rao, KA Dilley, JM Vargas, F Sheikh, RP Donnelly, RS Shabman, EG Meissner, L Prokunina-, OO Onabajo IFN-?4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling J. Immunol., 2017;0(0):. 2017 [PMID: 29070670] (Bioassay, Human) Bioassay Human
Show All 31 Publications.

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Gene Symbol IFNL1