Recombinant Human IL-28A/IFN-lambda 2 (HEK293) Protein


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human IL-28A/IFN-lambda 2 (HEK293) Protein Summary

Details of Functionality
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al. (2003) Nat. Immunol. 4:63. The ED50 for this effect is 5-25 ng/mL.
Human embryonic kidney cell, HEK293-derived human IL-28A/IFN-lambda 2 protein
Accession #
N-terminal Sequence
Val26 & Val28
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE with silver staining
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
20 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
20-23 kDa, reducing condtions
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8417-IL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>95%, by SDS-PAGE with silver staining
Reconstitution Instructions
Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-28A/IFN-lambda 2 (HEK293) Protein

  • interleukin-28A
  • IFN-lambda 2
  • IL28A
  • IL-28A
  • interferon, lambda 2


IL‑28A (Interferon-lambda 2; IFN-lambda 2), IL-28B/IFN-lambda 3, and IL-29/IFN-lambda 1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines (1‑3). Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity (4). It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. Type III interferons are upregulated in response to viral infection, and they act predominantly on epithelial cells through a receptor complex that contains IL-10 R beta and IL-28 R alpha /IFN-gamma R1 (4-6). Type III IFNs function as anti-viral molecules and induce the upregulation of MHC class I antigen (4, 5, 7). IL-28A promotes the Th1 polarization of dendritic cells in the airway (e.g. production of IL-12 p70 and IFN-gamma ) and inhibits Th2 and Th17 mediated inflammation (8). In the liver, however, the IL-28A induced Th1 cytokine response contributes to inflammation in T cell mediated hepatitis (9). IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo (10-12). In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration (13).
  1. Durbin, R.K. et al. (2013) Immunol. Rev. 255:25.
  2. Li, Q. et al. (2013) Front. Biosci. (Landmark Ed.) 18:909.
  3. Lopusna, K. et al. (2013) Acta Virol. 57:171.
  4. Ank, N. et al. (2006) J. Virol. 80:4501.
  5. Sheppard, P. et al. (2003) Nature Immunol. 4:63.
  6. Kotenko, S.V. et al. (2003) Nature Immunol. 4:69.
  7. Pott, J. et al. (2011) Proc. Natl. Acad. Sci. USA 108:7944.
  8. Koltsida, O. et al. (2011) EMBO Mol. Med. 3:348.
  9. Siebler, J. et al. (2007) Gastroenterology 132:358.
  10. Sato, A. et al. (2006) J. Immunol. 176:7686.
  11. Tezuka, Y. et al. (2012) Lung Cancer 78:185.
  12. Numasaki, M. et al. (2007) J. Immunol. 178:5086.
  13. Lee, S.J. et al. (2012) PLoS ONE 7:e40267.

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Gene Symbol IFNL2