Recombinant Human IL-26/AK155 Dimer Protein


There are currently no images for IL-26/AK155 (1870-IL).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Recombinant Human IL-26/AK155 Dimer Protein Summary

Details of Functionality
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Hor, S. et al. (2004) J. Biol. Chem. 279:33343. The ED50 for this effect is 10-75 ng/mL.
E. coli-derived human IL-26/AK155 protein
Lys22-Gln171, with an N-terminal Met
Accession #
N-terminal Sequence
Structure / Form

Disulfide-linked homodimer

Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
17.7 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
18 kDa, reducing conditions
36 kDa, non-reducing conditions
Read Publications using
1870-IL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
Supplied as a 0.2 μm filtered solution in NaH2PO4, NaCl and Glycerol with BSA as a carrier protein.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-26/AK155 Dimer Protein

  • AK155
  • AK155IL-26interleukin-26
  • IL26
  • IL-26
  • interleukin 26
  • Protein AK155


IL-26 was originally cloned from herpesvirus saimiri (HVS)-transformed T-cells and named AK155 (1). It is a member of the IL-10 family of class II cytokines that signal via heterodimeric receptor complexes composed of two type I transmembrane receptor subunits (2). The human IL-26 gene has been mapped to chromosome 12q15. It encodes a 171 amino acid polypeptide with a 21 amino acid signal peptide. In addition to HVS-transformed T cells, IL-26 is also expressed in other virus transformed T cell lines, fresh peripheral mononuclear cells, activated NK cells and T cells. A mouse homologue of human IL-26 has not been identified. IL-26 binds with high-affinity to the heterodimeric complex consisting of the ligand-binding IL-20 R alpha and non ligand-binding IL-10 R beta (3). Activation of the receptor complex results in rapid phosphorylation of STAT1 and STAT3. Although the IL-26 receptor complex is highly specific for IL-26 and is not activated by other class II cytokines, the individual subunits of the IL-26 receptor complex are components in receptor complexes for other class II cytokines (1). IL-20 R alpha can form dimers with IL‑20 R beta to function as signaling receptors for IL-19, IL-20, and IL-24. IL-10 R beta  can complex with IL-10 R alpha, IL-22 R, and IL-28 R alpha  to transduce signals for IL-10, IL-22, and the three novel IFNs (IL-28A, IL-28B and IL-29), respectively. The physiological functions of IL-26 remain to be determined.

IL-26 was reported to be a homodimer in solution (1). E. coli-derived IL-26 produced by R&D Systems contains disulfide-linked homodimers and monomers. Both the pure monomeric and dimeric IL-26 can bind directly to IL-20 R alpha  and induce STAT activation in COLO-205 cells (4). Besides IL-20 R alpha, R&D Systems IL-26 preparations have also been shown to bind IL‑20 R beta. The significance of this receptor-ligand interaction has not been investigated.

  1. Knappe. A. et al. (2000) J. Virology 74:3881.
  2. Renauld, J.-C. (2003) Nature Reviews Immunology 3:667.
  3. Sheikh, F. et al. (2004) J. Immunol. 172:2006.
  4. Unpublished data (2003) R&D Systems, Inc.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IHC, CyTOF-ready, ICFlow
Species: Mu
Applications: WB, Block, CyTOF-ready, ELISA(Cap), ELISA(Det), ICFlow, ELISA(Sta)
Species: Hu
Species: Hu
Applications: WB, IHC, IHC-P
Species: Mu
Species: Hu
Applications: WB, Flow, CyTOF-ready, Neut
Species: Mu
Species: Hu, Mu
Applications: WB, Flow
Species: Hu
Species: Hu, Mu, Rt, Mk, Pm
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP, KD
Species: Hu, Mu
Applications: WB, Simple Western, CyTOF-ready, ICFlow
Species: Hu
Species: Hu
Applications: Bioactivity

Publications for IL-26/AK155 (1870-IL)(4)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Binding Assay, Bioassay, In Vivo.

Filter By Application
Binding Assay
In Vivo
All Applications
Filter By Species
All Species

Reviews for IL-26/AK155 (1870-IL) (0)

There are no reviews for IL-26/AK155 (1870-IL). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for IL-26/AK155 (1870-IL) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Array Products

Bioinformatics Tool for IL-26/AK155 (1870-IL)

Discover related pathways, diseases and genes to IL-26/AK155 (1870-IL). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-26/AK155 (1870-IL)

Discover more about diseases related to IL-26/AK155 (1870-IL).

Pathways for IL-26/AK155 (1870-IL)

View related products by pathway.

PTMs for IL-26/AK155 (1870-IL)

Learn more about PTMs related to IL-26/AK155 (1870-IL).

Blogs on IL-26/AK155

There are no specific blogs for IL-26/AK155, but you can read our latest blog posts.

Customers Who Bought This Also Bought

IL-6 [Unconjugated]

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Human IL-26/AK155 Dimer Protein and receive a gift card or discount.


Gene Symbol IL26