Rap2B Antibody (455517) [Alexa Fluor® 405]

• Applications: WB
• Clone: 455517
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Rap2B Antibody (455517) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human Rap2B
  Met1-Leu183
  Accession # P61225
• Specificity: Detects human Rap2B in Western blots. No cross-reactivity with recombinant human Rap2A is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Rap2B is a member of the small GTPase superfamily and ras family of proteins. Unlike normal ras proteins that have a nontransforming glutamine residue at aa 61, Rap2B has a threonine residue in that position. This change makes the intrinsic GTPase activity for Rap2B lower, thereby allowing it to exist in the activated state for a longer period of time than normal ras proteins. Aggregation of platelets by thrombin results in the activation of Rap2B in a Ca²⁺ and PI3 kinase-dependent manner.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.