PTGER3 Antibody (5F5)

Product Discontinued

PTGER3 Antibody (5F5) Summary

• Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human EP3 receptor protein and mouse myeloma cells.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTGER3
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1 - 5 ug/mL
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for PTGER3 Antibody (5F5)

• EP3
• EP3EP3e
• EP3-I
• EP3-II
• EP3-III
• EP3-IV
• MGC141828
• MGC141829
• MGC27302
• PGE receptor EP3 subtype
• PGE receptor, EP3 subtype
• PGE2 receptor EP3 subtype
• PGE2-R
• prostaglandin E receotor EP3 subtype 3 isoform
• prostaglandin E receptor 3 (subtype EP3)
• prostaglandin E2 receptor EP3 subtype
• prostaglandin receptor (PGE-2)
• Prostanoid EP3 receptor
• PTGER3

Background

Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP3 receptors are 365-425 amino acid proteins. There are currently 4 known isoforms of EP3 receptors named EP3A, 3B, 3C and 3D. Each of has different physiological function, but differ only in the carboxyl terminus and how they couple to their respective G-proteins. EP3 receptors are involved in water absorption, gastric acid secretion, uterine contraction, neurotransmitter release and the hydrolysis of fat cells (lipolysis). EP3 receptors also act as a mediator of neural inflammation. These receptors are mainly localized in the brain, kidney, stomach, uterus and ovaries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for PTGER3 Antibody (NBP2-66637). (Showing 1 - 1 of 1 FAQ).

1. I received an e-mail about some complimentary antibody samples that are available. We work with Ptger3 and have tried several antibodies (Santa Cruz, Abcam, Cayman) but haven't found an antibody that works. I was wondering if you would be willing to send us a complimentary sample of your Ptger3 antibody to test? If it works, we will likely buy a decent amount.
   • A list of our Ptger3 antibodies can be found here. It is company policy that we do not give out free samples as we have a 100% guarantee on all of our products for the applications and species listed on the datasheet. The email you received about free samples only applies to the antibodies listed in the email, of which Ptger3 is not listed.

Bioinformatics

• Gene Symbol: PTGER3