PRTFDC1 Antibody - BSA Free

Western Blot: PRTFDC1 Antibody [NBP1-76358] - Human brain tissue lysate with PRTFDC1 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.

• Reactivity: Hu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

PRTFDC1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit PRTFDC1 Antibody - BSA Free (NBP1-76358) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1. The immunogen is located within amino acids 90 - 140 of PRTFDC1. Amino Acid Squence: MKVDFIRLKSYRND
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PRTFDC1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1 ug/ml
• Control Peptide:

  PRTFDC1 Peptide (NBP1-76358PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (86%), Porcine (86%), Bovine (86%), Mouse (86%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for PRTFDC1 Antibody - BSA Free

• EC 2.4.2.8
• FLJ11888
• HHGPEC 2.4.2
• phosphoribosyl transferase domain containing 1
• phosphoribosyltransferase domain-containing protein 1

Background

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRTFDC1
• Uniprot:
  • NP_064585(Human)