Prostaglandin I2 Synthase Antibody (852307) [DyLight 594]

• Reactivity: Hu
• Applications: WB
• Clone: 852307
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 594

Prostaglandin I2 Synthase Antibody (852307) [DyLight 594] Summary

• Immunogen: E. coli-derived recombinant human Prostaglandin I2 Synthase
  Arg21-Pro500
  Accession # Q16647
• Specificity: Detects human Prostaglandin I2 Synthase in ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTGIS
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Prostaglandin I2 Synthase Antibody (852307) [DyLight 594]

• CYP8
• CYP8A1
• CYP8A1PTGI
• CYP8prostacyclin synthase
• EC 5.3.99.4
• MGC126858
• MGC126860
• PGIS
• PGIScytochrome P450, family 8, subfamily A, polypeptide 1
• Prostacyclin Synthase
• prostaglandin I2 (prostacyclin) synthase
• Prostaglandin I2 synthase
• PTGI
• PTGIS

Background

PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTGIS