Orthogonal Strategies: Immunohistochemistry-Paraffin: PRICKLE1 Antibody [NBP1-83967] - Analysis in human cerebral cortex and skeletal muscle tissues. Corresponding PRICKLE1 RNA-seq data are presented for the same ...read more
Immunocytochemistry/ Immunofluorescence: PRICKLE1 Antibody [NBP1-83967] - Staining of human pancreatic frozen tissue sections stained with PRICKLE1 antibody (red). Nuclei labeled with DAPI (blue). Image from verified ...read more
Immunohistochemistry-Paraffin: PRICKLE1 Antibody [NBP1-83967] - Staining of human fallopian tube shows weak to moderate nuclear positivity in glanular cells.
Immunohistochemistry-Paraffin: PRICKLE1 Antibody [NBP1-83967] - Staining of human testis shows moderate nuclear postivity in cells in seminiferous ducts.
Immunohistochemistry-Paraffin: PRICKLE1 Antibody [NBP1-83967] - Staining of human cerebral cortex shows moderate strong nuclear positivity in neurons.
Immunohistochemistry-Paraffin: PRICKLE1 Antibody [NBP1-83967] - Staining of human skeletal muscle shows no postivity in myocytes as expected.
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PRICKLE1 Antibody Summary
This antibody was developed against Recombinant Protein corresponding to amino acids: GASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEI
Mouse (91%), Rat (94%). Backed by our 100% Guarantee.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2) and 40% Glycerol
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for PRICKLE1 Antibody
prickle homolog 1 (Drosophila)
prickle-like 1 (Drosophila)
prickle-like protein 1
REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencerfactor)-interacting LIM domain protein
REST/NRSF-interacting LIM domain protein 1
PRICKLE1 has 831 amino acids and is approximately 94kDa. PRICKLE1 localizes to the nuclear membrane and is involved in the movement of REST, a transcription repressor. PRICKLE1 is implicated in pathways that regulate neural tube development and gastrulation. PRICKLE1 may also be a nuclear receptor that negatively regulates the Wnt/beta-catenin signaling pathway. Current research on PRICKLE1 is being performed in relation to several diseases and disorders including neural tube defects and progressive myoclonic epilepsy type 1B. PRICKLE1 has also been shown to interact with Dishevelled 1, Dishevelled 2, Dishevelled 3, VIP, and SMURF2 in the Wnt signaling pathway.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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