PRICKLE1 Products

Description

PRICKLE1 has 831 amino acids and is approximately 94kDa. PRICKLE1 localizes to the nuclear membrane and is involved in the movement of REST, a transcription repressor. PRICKLE1 is implicated in pathways that regulate neural tube development and gastrulation. PRICKLE1 may also be a nuclear receptor that negatively regulates the Wnt/beta-catenin signaling pathway. Current research on PRICKLE1 is being performed in relation to several diseases and disorders including neural tube defects and progressive myoclonic epilepsy type 1B. PRICKLE1 has also been shown to interact with Dishevelled 1, Dishevelled 2, Dishevelled 3, VIP, and SMURF2 in the Wnt signaling pathway.

Bioinformatics

Entrez	144165 Human
Uniprot	NM_153026 Human NP_694571 Human
Product By Gene ID	144165
Alternate Names	EPM1BMGC138902 FLJ31627 FLJ31937 prickle homolog 1 (Drosophila) prickle-like 1 (Drosophila) prickle-like 1 prickle-like protein 1 REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencerfactor)-interacting LIM domain protein REST/NRSF-interacting LIM domain protein 1 RILPMGC138903

Research Areas for PRICKLE1

Find related products by research area and learn more about each of the different research areas below.

Wnt Signaling Pathway