PPP2R2A Antibody (2G9)

Product Discontinued

PPP2R2A Antibody (2G9) Summary

• Immunogen: Peptide from rat PP2A B/PR55 isoform alpha
• Specificity: It recognizes isoforms alpha and rat delta very well , weakly the human beta isoform, very weakly the rabbit gamma isoform
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PPP2R2A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:50
  • Western Blot 1:1000

Reactivity Notes

rabbit xenopus Sus Scrofa (pig) Chicken

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 30% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PPP2R2A Antibody (2G9)

• B55A
• B55ALPHA
• DKFZp686N05117
• FLJ26613
• FLJ41727
• MGC52248
• PP2A subunit B isoform alpha
• PP2A subunit B isoform B55-alpha
• PP2A subunit B isoform PR55-alpha
• PP2A subunit B isoform R2-alpha
• PR52A
• PR55A
• protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alphaisoform
• protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
• protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
• protein phosphatase 2, regulatory subunit B, alpha
• serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alphaisoform
• serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alphaisoform

Background

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPP2R2A
• Uniprot:
  • P36876(Rat)