Phospholamban Antibody

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Western Blot: Phospholamban Antibody [NBP1-49852] - Analysis of Phospholamban in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-49852 at 0.03ug/ml. Primary incubation was 1 hour. Detected by ...read more

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

Phospholamban Antibody Summary

Immunogen
Peptide with sequence KVQYLTRSAIRR-C corresponding to N-Terminus according to NP_002658.1.
Epitope
KVQYLTRSAIRR - N Terminus
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PLN
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.01 - 0.03 ug/ml
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: Approx. 13 kDa band observed in human and rat heart lysates (calculated MW of 6.11 kDa band according to NP_002658.1).
Publications
Read Publication using NBP1-49852.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Porcine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Phospholamban Antibody

  • CMD1PPLBcardiac phospholamban
  • phospholamban

Background

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Phospholamban Antibody (NBP1-49852)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Phospholamban Antibody (NBP1-49852)

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Bioinformatics

Gene Symbol PLN
Entrez
Uniprot