PDE6A Antibody

Western Blot: PDE6A Antibody [NB120-5660] - Analysis of PDE6 alpha’ on sheep retinal extracts.

Product Discontinued

PDE6A Antibody Summary

• Immunogen: Synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha'.
• Localization: Plasma membrane
• Specificity: PDE6 alpha’
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDE6A
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: WB: Detects an approx. 90 kDa representing PDE6 alpha' from sheep retinal extract.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Purity: Ammonium sulfate precipitation

Alternate Names for PDE6A Antibody

• CGPR-A
• EC 3.1.4
• EC 3.1.4.35
• GMP-PDE alpha
• PDE V-B1
• PDE6A
• PDEA
• PDEAcGMP phosphodiesterase alpha subunit
• phosphodiesterase 6A, cGMP-specific, rod, alpha
• rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit alpha
• rod photoreceptor cGMP phosphodiesterase alpha subunit
• RP43

Background

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDE6A
• Entrez:
  • 281973(Bovine)