P2Y1/P2RY1 Antibody - BSA Free

Immunohistochemistry-Paraffin: P2Y1/P2RY1 Antibody [NLS387] - Analysis of anti-P2RY1 / P2Y1 antibody with human brain, neurons and glia.

Immunohistochemistry: P2Y1/P2RY1 Antibody - BSA Free [NLS387] - Immunohistochemistry of Lung, adenocarcinoma

• Reactivity: Hu, Rt, Bt, Po, Av, Bv, Ch, Eq, Gp, Ha, Pm, Pm, Rb
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

P2Y1/P2RY1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 15 amino acid peptide from 2nd extracellular domain of human P2Y1/P2RY1.
• Epitope: 2nd extracellular domain
• Specificity: Human P2Y1/P2RY1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Porcine (93%), Bovine (93%), Guinea Pig (93%), Rabbit (93%), Avian (93%), Monkey (93%), Primate (100%), Equine (93%), Hamster (93%), Chicken (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: P2RY1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2.5 ug/ml
• Application Notes: Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 25683778)..

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Mouse (87%), Rat (87%), Elephant (87%), Xenopus (87%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for P2Y1/P2RY1 Antibody - BSA Free

• ATP receptor
• P2 purinoceptor subtype Y1
• P2RY1
• P2Y purinoceptor 1
• P2Y1
• P2Y1platelet ADP receptor
• purinergic receptor P2Y, G-protein coupled, 1
• Purinergic receptor

Background

P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for P2Y1/P2RY1 Antibody (NLS387)(1)

Publication using NLS387

• Heine C, Sygnecka K, Scherf N et al. P2Y1 receptor mediated neuronal fibre outgrowth in organotypic co-cultures Neuropharmacology. 2015-02-13 [PMID: 25683778] (ICC/IF, Rat)

Bioinformatics

• Gene Symbol: P2RY1
• Entrez:
  • 5028(Human)
• Uniprot:
  • P47900(Human)