Recombinant Human NR6/CLC Protein

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SDS-Page: Recombinant Human NR6/CLC Protein [NBP1-72423] - 15% SDS-PAGE (3ug)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human NR6/CLC Protein Summary

Description
A denatured recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 28-225 of Human NR6/CLC

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
CLCF1
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
24.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM sodium citrate (pH 3.5), 0.4M urea, 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human NR6/CLC Protein

  • B-cell stimulating factor 3
  • B-cell stimulatory factor 3
  • BSF-3
  • BSF3BSF-3
  • cardiotrophin-like cytokine factor 1
  • CISS2
  • CLC
  • CLCF1
  • CLCNNT-1
  • CRLF1 associated cytokine-like factor 1
  • neurotrophin-1/B-cell stimulating factor-3
  • NNT-1
  • NNT1B-cell-stimulating factor 3
  • Novel neurotrophin-1
  • NR6

Background

CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CLCF1
Entrez