Nav1.8 Antibody (S134-12)


Immunohistochemistry: Nav1.8 Antibody (S134-12) [NBP1-47615] - Mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada.
Immunocytochemistry/ Immunofluorescence: Nav1.8 Antibody (S134-12) [NBP1-47615] - Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal more
Immunocytochemistry/ Immunofluorescence: Nav1.8 Antibody (S134-12) [NBP1-47615] - Tissue: backskin. Species: Mouse. Fixation: Bouins Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal more
Western Blot: Nav1.8 Antibody (S134-12) [NBP1-47615] - analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12. Load: 15 ug protein. more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
1 mg/ml

Nav1.8 Antibody (S134-12) Summary

Fusion protein amino acids 1724-1956 (cytoplamic C-terminus) of rat Nav1.8 (also known as channel protein type 10 or x subunit alpha, peripheral nerve sodium channel 3, PN3 or Sensory neuron sodium channel (NP_058943.1).
This product is specific for 220kDa Nav1.8 Na+ Channel. No cross reactivity against other Nav channels
Protein G purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS pH7.4, 50% glycerol
0.09% Sodium Azide
1 mg/ml
Protein G purified


  • Western Blot 1-10 ug/ml
  • Immunocytochemistry/Immunofluorescence 0.1-1.0 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 0.1-1.0 ug/ml

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.


1mg/mL; WB: 1ug/mL (if results are poor, use the lysate in SDS buffer but without boiling, incubate for 20 mins at 37 degrees C); IHC/ICC: 0.1-1.0ug/mL (Perox), 1.0-10ug/mL (IF)

Alternate Names for Nav1.8 Antibody (S134-12)

  • hPN3
  • Nav1.8
  • PN3
  • sodium channel protein type 10 subunit alpha
  • sodium channel protein type X subunit alpha
  • sodium channel, voltage-gated, type X, alpha subunit
  • voltage-gated, type X, alpha polypeptide


Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (3).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NBP1-47615AF405
Alexa Fluor (R) 488 Labeled NBP1-47615AF488
Alexa Fluor (R) 647 Labeled NBP1-47615AF647
Alexa Fluor (R) 700 Labeled NBP1-47615AF700
Allophycocyanin Labeled NBP1-47615APC
DyLight 350 Labeled NBP1-47615UV
DyLight 405 Labeled NBP1-47615V
DyLight 405LS Labeled NBP1-47615V3
DyLight 488 Labeled NBP1-47615G
DyLight 680 Labeled NBP1-47615FR
DyLight 755 Labeled NBP1-47615IR
PE Labeled NBP1-47615PE
PerCP Labeled NBP1-47615PCP

Additional Nav1.8 Antibody (S134-12) Products

Nav1.8 NBP1-47615

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Contact Information

Product PDFs


Gene Symbol SCN10A

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