Recombinant Human Nav1.5 Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, PA

Order Details

Recombinant Human Nav1.5 Protein Summary

Description
A recombinant protein with GST tag at N-terminal corresponding to the amino acids 1-223 of Human SCN5A full-length ORF

Source: Wheat Germ (in vitro)

Amino Acid Sequence:MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAASVLGTLFFPMSIQATSTS

Details of Functionality
This protein is not active and should not be used for experiments requiring activity.
Protein/Peptide Type
Recombinant Protein
Gene
SCN5A
Purity
>80%, by SDS-PAGE

Applications/Dilutions

Application Notes
This protein has not been tested for any functionality. Product may contain endotoxins and is not suitable for use with live cells.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Purity
>80%, by SDS-PAGE

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human Nav1.5 Protein

  • cardiac sodium channel alpha subunit
  • cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
  • CDCD2VF1
  • HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
  • HB2
  • HBBD
  • HH1CMD1E
  • ICCD
  • IVF
  • LQT3SSS1CMPD2
  • Nav1.5
  • PFHB1
  • Sodium channel protein cardiac muscle subunit alpha
  • sodium channel protein type 5 subunit alpha
  • sodium channel protein type V alpha subunit
  • Sodium channel protein type V subunit alpha
  • sodium channel, voltage-gated, type V, alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.5

Background

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol SCN5A