Nav1.5 Antibody (4G8:1G7) [DyLight 550]

Product Discontinued

Nav1.5 Antibody (4G8:1G7) [DyLight 550] Summary

• Immunogen: Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: SCN5A
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
  • Radioimmunoassay
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Nav1.5 Antibody (4G8:1G7) [DyLight 550]

• cardiac sodium channel alpha subunit
• cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
• CDCD2VF1
• HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
• HB2
• HBBD
• HH1CMD1E
• ICCD
• IVF
• LQT3SSS1CMPD2
• Nav1.5
• PFHB1
• SCN5A
• Sodium channel protein cardiac muscle subunit alpha
• sodium channel protein type 5 subunit alpha
• sodium channel protein type V alpha subunit
• Sodium channel protein type V subunit alpha
• sodium channel, voltage-gated, type V, alpha subunit
• Voltage-gated sodium channel subunit alpha Nav1.5

Background

Nav1.5 is encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. This antibody is expected to recognise both reported isoforms (NP_000326 and NP_932173).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SCN5A