MYO18A Antibody

Immunohistochemistry-Paraffin: MYO18A Antibody [NBP1-83020] - Staining of human cerebral cortex, colon, kidney and skeletal muscle using Anti-MYO18A antibody NBP1-83020 (A) shows similar protein distribution across tissues to independent antibody NBP1-83021 (B).

Immunohistochemistry-Paraffin: MYO18A Antibody [NBP1-83020] - Staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes.

Immunohistochemistry-Paraffin: MYO18A Antibody [NBP1-83020] - Staining of human cerebral cortex shows moderate positivity in neuropil.

Immunohistochemistry-Paraffin: MYO18A Antibody [NBP1-83020] - Staining of human colon shows moderate cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: MYO18A Antibody [NBP1-83020] - Staining of human kidney shows weak to moderate cytoplasmic and membranous positivity in cells in tubules.

Product Discontinued

MYO18A Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: RFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEP
• Predicted Species: Mouse (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MYO18A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (89%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for MYO18A Antibody

• KIAA0216DKFZp686L0243
• MAJN
• Molecule associated with JAK3 N-terminus
• myosin 18A
• Myosin containing a PDZ domain
• myosin containing PDZ domain
• myosin XVIIIA
• myosin-XVIIIa
• MysPDZ
• SP-A receptor subunit SP-R210 alphaS
• SPR210

Background

Myo18A/Myosin XVIIIA is an unconventional myosin that contains a lysine and glutamine (KE)-rich domain and a PDZ domain. The KE and PDZ domains appear to direct subcellular localization of the Myo18A variants. It is a dimeric actin binding protein that may play a role in the stabilization and organization of the actin cytoskeleton. Recently a cell surface form of Myo18A has been identified as the receptor for surfactant protein A, a lipid-associated lung collectin that mediates innate and adaptive immune responses in the lungs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MYO18A
• Entrez:
  • 399687(Human)
• Uniprot:
  • Q92614(Human)