Muscarinic Acetylcholine Receptor M4/CHRM4 Antibody (18C7.2)

• Reactivity: Hu, Rt, Pm
• Applications: WB, IHC, IP
• Clone: 18C7.2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: This product is unpurified. The exact concentration of antibody is not quantifiable.

Muscarinic Acetylcholine Receptor M4/CHRM4 Antibody (18C7.2) Summary

• Description: Relevant Entrez Gene Numbers: NM_000741.2
• Immunogen: m4 receptor i3 loop (human), fused to GST.
• Specificity: m4 muscarinic acetylcholine receptor. No reactivity with the other subtypes.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CHRM4
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Immunohistochemistry (monkey) Western Blot (transfected CHO cell lines) Immunoprecipitation (rat and monkey)

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Ascites with 20mM Phosphate and 0.25M NaCl
• Preservative: 0.1% Sodium Azide
• Concentration: This product is unpurified. The exact concentration of antibody is not quantifiable.
• Purity: Unpurified

Notes

Relevant Entrez Gene Numbers: NM_000741.2

Alternate Names for Muscarinic Acetylcholine Receptor M4/CHRM4 Antibody (18C7.2)

• cholinergic receptor, muscarinic 4
• CHRM4
• HM4
• M4
• M4R
• mAChR M4
• muscarinic acetylcholine receptor M4

Background

Muscarinic acetylcholine receptor M4 is an Acetylcholine Receptor. Unlike muscarinic receptor M2, the M4 receptor is not involved in smooth muscle contraction. The clinical relevance of this receptor is unknown. However, mouse studies have linked it to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus. ESTs have been isolated from human breast and eye libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CHRM4
• Uniprot:
  • P08173(Human)