mu Opioid R/OPRM1 Antibody

Western Blot: mu Opioid R/OPMR1 Antibody [NB100-1618] - Analysis of isolated mouse brain striatum and cerebellum for the non-phospho-MOR antibody or the MOR-P2 antibody. The samples from cerebellum demonstrate a lack of IR for both the non-phospho-MOR antibody and MOR-P2 antibody further showing the selectivity of these antibodies. The images are each representative of four independent experiments. Dilution 1:1000.

Immunocytochemistry/Immunofluorescence: mu Opioid R/OPMR1 Antibody [NB100-1618] - Staining of Mouse Dorsal Horn, using a 1:50 dilution of 1:50.

Immunohistochemistry: mu Opioid R/OPRM1 Antibody [NB100-1618] - Rat Dorsal Horn. Courtesy of Dr. Louis Gendron, University of Sherbrooke

Product Discontinued

mu Opioid R/OPRM1 Antibody Summary

• Immunogen: Synthetic peptide: NHQLENLEAETAPLP, corresponding to C terminal amino acids 384-398 of Rat Mu Opioid Receptor splice variant.
• Localization: Plasma membrane
• Specificity: Mu Opioid Receptor splice variant
• Isotype: IgG
• Clonality: Polyclonal
• Host: Guinea Pig
• Gene: OPRM1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-500
  • Immunohistochemistry Free-Floating
  • Immunohistochemistry 1:50-500
  • Western Blot 1:100-1:2000
• Application Notes: Use in IHC-FrFl reported in scientific literature (PMID:33766518).

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:33766518). Mouse (88%). Reactivity reported in scientific literature (PMID: 23354438)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 50% glycerol
• Preservative: No Preservative
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mu Opioid R/OPRM1 Antibody

• hMOP
• KIAA0403
• LMOR
• MOP
• mOpioidR
• MOR
• MOR1
• M-OR-1
• MOR-1
• MOR1MOR
• Mu opiate receptor
• mu Opioid R
• Mu opioid receptor
• mu-type opioid receptor
• opioid receptor, mu 1
• OPRM
• OPRM1

Background

The powerful effects of opiate are mediated through the opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for mu Opioid R/OPRM1 Antibody (NB100-1618)(2)

Publications using NB100-1618

• Lee GJ, Kim SA, Kim YJ, Oh SB Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain Brain research 2021-03-22 [PMID: 33766518] (IHC-FrFl, Mouse)
• Weber L, Wang X, Ren R et al. The Development of a Macromolecular Analgesic for Arthritic Pain Mol. Pharm. 2019-03-04 [PMID: 30702897] (IF/IHC, Rat)

FAQs for mu Opioid R/OPRM1 Antibody (NB100-1618). (Showing 1 - 1 of 1 FAQs).

1. Is this antibody against mu-type opioid receptor 1? Any data avaiable for mouse striatum section?
   • NB100-1618 is a guinea pig polyclonal antibody against Mu Opioid Receptor. We have not tested this antibody on mouse striatum, and I regret that I cannot provide additional information about that sample type.

Bioinformatics

• Gene Symbol: OPRM1
• Entrez:
  • 4988(Human)
  • 25601(Rat)
• Uniprot:
  • P33535()