MTRR Antibody (1G7)

Western Blot: MTRR Antibody (1G7) [H00004552-M01] - Detection against Immunogen (37.84 KDa) .

Product Discontinued

MTRR Antibody (1G7) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: MTRR (NP_002445, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MRRFLLLYATQQGQAKAIAEEMCEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKI
• Localization: Cytoplasmic and Mitochondrial
• Specificity: MTRR - 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MTRR
• Purity: Ascites

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Ascites

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MTRR Antibody (1G7)

• [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)
• 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
• cblE
• EC 1.16.1.8
• methionine synthase reductase
• methionine synthase reductase, mitochondrial
• MGC129643
• MSR

Background

Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MTRR Antibody (H00004552-M01)(1)

Publication using H00004552-M01

• Guise CP, Abbattista MR, Tipparaju SR et al. Diflavin Oxidoreductases Activate the Bioreductive Prodrug PR-104A under Hypoxia. Mol Pharmacol. 2011-10-07 [PMID: 21984255]

Bioinformatics

• Gene Symbol: MTRR
• Entrez:
  • 4552(Human)
• OMIM:
  • 182(Human)
• Uniprot:
  • NP_002445(Human)