MTRR Products

Description

Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Bioinformatics

Entrez	4552 Human
Uniprot	NP_002445 Human
Product By Gene ID	4552
Alternate Names	[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase cblE EC 1.16.1.8 methionine synthase reductase methionine synthase reductase, mitochondrial MGC129643 MSR

Research Areas for MTRR

Find related products by research area and learn more about each of the different research areas below.

Amino Acids, Drugs and other small molecules
Cancer
Signal Transduction