MTRR Products

Antibodies
MTRR Antibody
MTRR Antibody
NBP1-57749
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
MTRR Antibody
MTRR Antibody
NBP1-86596
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MTRR Antibody (1G7)
MTRR Antibody (1G7)
H00004552-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
MTRR Overexpression Lysate (N ...
MTRR Overexpression Lysate (Native)
NBL1-13385
Applications: WB
Proteins
MTRR Partial Recombinant Prot ...
MTRR Partial Recombinant Protein
H00004552-Q01
Species: Hu
Applications: WB, ELISA, PA
MTRR Recombinant Protein Anti ...
MTRR Recombinant Protein Antigen
NBP1-86596PEP
Species: Hu
Applications: AC
RNAi
MTRR RNAi
MTRR RNAi
H00004552-R01
Species: Hu
Applications: RNAi, RNAi SP
MTRR RNAi
MTRR RNAi
H00004552-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

MTRR, also known as Methionine synthase reductase, consists of 3 isoforms, a 725 amino acid isoform 1 that is 80 kDa, a 658 amino acid isoform 2 that is 78 kDa and 58 amino acid isoform 2 that is 6 kDa, cytoplasm located, found in all tissues tested, particularly abundant in skeletal muscle, regenerates a functional methionine synthase via reductive methylation, and it is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Current research is being performed onseveral diseases and disorders including homocystinuria-megaloblastic anemia cbl e type, neural tube defects folate-sensitive, homocystinuria-megaloblastic anemia, neural tube defect, cble, disorders of intracellular cobalamin metabolism, megaloblastic anemia, homocysteine, diffuse large b-cell lymphoma, homocysteine plasma level, cleft lip/palate, age related macular degeneration, deep vein thrombosis, homocystinuria, patent ductus arteriosus, spina bifida, b-cell lymphomas, methylcobalamin deficiency, abdominal aortic aneurysm, hyperhomocysteinemia, and Down syndrome. The protein has been linked to the Antimetabolite Pathway - Folate Cycle, Pharmacodynamics, Methotrexate Pathway (Cancer Cell) Pharmacodynamics, Thiopurine Pathway Pharmacokinetics/Pharmacodynamics, One Carbon Metabolism, Folate Metabolism, Sulfur amino acid metabolism, Biological oxidations, Metabolism of amino acids and derivatives, and Phase II conjugation pathways where it interacts with MMAB, ELAVL1, and UBC proteins.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 4552
Alternate Names
  • EC 1.16.1.8
  • MGC129643
  • methionine synthase reductase, mitochondrial
  • MSR
  • methionine synthase reductase
  • cblE
  • [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

PTMs for MTRR

Learn more about PTMs related to MTRR.

Methylation
Reduction
Acetylation
Phosphorylation
Cleavage
Oxidation

Bioinformatics Tool for MTRR

Discover related pathways, diseases and genes to MTRR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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