MTAP Antibody (MTAP/1813) [Alexa Fluor® 532]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clone
MTAP/1813
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 532

MTAP Antibody (MTAP/1813) [Alexa Fluor® 532] Summary

Immunogen
Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
Localization
Cytoplasmic
Specificity
Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MTAP
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for MTAP Antibody (MTAP/1813) [Alexa Fluor® 532]

  • 5'-methylthioadenosine phosphorylase
  • BDMF
  • C86fus
  • DMSFH
  • DMSMFH
  • EC 2.4.2.28
  • HEL-249
  • LGMBF
  • methylthioadenosine phosphorylase
  • MSAPMeSAdo phosphorylase
  • MTA phosphorylase
  • MTAP
  • MTAPase
  • S-methyl-5'-thioadenosine phosphorylase

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-75731AF350
Alexa Fluor 405 NBP2-75731AF405
Alexa Fluor 488 NBP2-75731AF488
Alexa Fluor 532 NBP2-75731AF532
Alexa Fluor 594 NBP2-75731AF594
Alexa Fluor 647 NBP2-75731AF647
Alexa Fluor 700 NBP2-75731AF700
Alexa Fluor 750 NBP2-75731AF750
Biotin NBP2-75731B
DyLight 350 NBP2-75731UV
DyLight 405 NBP2-75731V
DyLight 488 NBP2-75731G
DyLight 550 NBP2-75731R
DyLight 594 NBP2-75731DL594
DyLight 650 NBP2-75731C
DyLight 680 NBP2-75731FR
DyLight 755 NBP2-75731IR
FITC NBP2-75731F
HRP NBP2-75731H
Janelia Fluor 549 NBP2-75731JF549
Janelia Fluor 646 NBP2-75731JF646

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Bioinformatics Tool for MTAP Antibody (NBP2-75731AF532)

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Bioinformatics

Gene Symbol MTAP