Mouse Meteorin-like/METRNL DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Meteorin-like/METRNL DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Metrnl

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Meteorin-like/METRNL DuoSet ELISA, 15 Plate

• Meteorin like
• meteorin, glial cell differentiation regulator-like
• meteorin-like protein
• Meteorin-like
• METRNL
• MGC99788

Background

METRNL (Meteorin-like) is a cytoplasmic 30 kDa (predicted) member of the meteorin family of proteins. The name meteorin derives from the ability of the founding family member meteorin to transform glia into cells containing an extensive, meteor-like tail. It is expressed by neurons, and appears to function as a primer molecule that sets the stage for either cell differentiation or neurite outgrowth when it acts with Dclk1 and SerpinB1. Mature human METRNL is 266 amino acids (aa) in length (aa 46-311). It reportedly contains a signal sequence (aa 1-45), which suggests it may be secreted. Mature human and mouse METRNL share 79% aa sequence identity.

Publications for Meteorin-like/METRNL (DY6679)(9)

Publications using DY6679

• DE Lee, LK McKay, A Bareja, Y Li, A Khodabukus, N Bursac, GA Taylor, GS Baht, JP White Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling Nature Communications, 2022-12-09;13(1):7613. 2022-12-09 [PMID: 36494364] (Mouse)
• YW Dai, JK Ma, R Jiang, XL Zhan, SY Chen, LL Feng, Q Zhang, TB Liang, K Lv, GJ Yang, JF Lu, J Chen, XJ Lu Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization Cell Reports, 2022-09-20;40(12):111361. 2022-09-20 [PMID: 36130501] (Mouse)
• HMA Javaid, NE Sahar, DL ZhuGe, JY Huh Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like Cells, 2021-12-09;10(12):. 2021-12-09 [PMID: 34943988] (Mouse)
• AJ Knights, EJ Vohralik, PJ Houweling, ES Stout, LJ Norton, SJ Alexopoulo, JJ Yik, H Mat Jusoh, EM Olzomer, KS Bell-Ander, KN North, KL Hoehn, M Crossley, KGR Quinlan Eosinophil function in adipose tissue is regulated by Kr�ppel-like factor 3 (KLF3) Nat Commun, 2020-06-10;11(1):2922. 2020-06-10 [PMID: 32523103] (Mouse)
• TW Jung, SH Lee, HC Kim, JS Bang, AM Abd El-Aty, A Hac?müftüo, YK Shin, JH Jeong METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR?-dependent pathways in skeletal muscle of mice Exp. Mol. Med., 2018-09-13;50(9):122. 2018-09-13 [PMID: 30213948] (Mouse)
• JY Bae Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice Biomed Res Int, 2018-04-30;2018(0):6283932. 2018-04-30 [PMID: 29854769] (Mouse)
• JY Bae, J Woo, S Kang, KO Shin Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice Lipids Health Dis, 2018-04-27;17(1):97. 2018-04-27 [PMID: 29703203] (Mouse)
• Li Z, Song J, Zheng S, Fan M, Guan Y, Qu Y, Xu J, Wang P, Miao C Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARgamma Signaling. Diabetes, 2015-08-25;64(12):4011-22. 2015-08-25 [PMID: 26307585] (Mouse)
• Ushach I, Burkhardt A, Martinez C, Hevezi P, Gerber P, Buhren B, Schrumpf H, Valle-Rios R, Vazquez M, Homey B, Zlotnik A METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages. Clin Immunol, 2014-12-05;156(2):119-127. 2014-12-05 [PMID: 25486603] (Mouse)

Bioinformatics

• Gene Symbol: Metrnl