Mouse DPPIV/CD26 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse DPPIV/CD26 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Dpp4

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse DPPIV/CD26 DuoSet ELISA, 15 Plate

• ADABP
• ADCP-2
• ADCP2DPP IV
• Adenosine deaminase complexing protein 2TP103
• CD26 antigen
• CD26
• CD26T-cell activation antigen CD26
• dipeptidyl peptidase 4
• Dipeptidyl peptidase IV
• dipeptidylpeptidase 4
• dipeptidyl-peptidase 4
• dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
• DPP4
• DPPIV
• EC 3.4.14.5

Background

DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P). DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.

Publications for DPPIV/CD26 (DY954)(8)

Publications using DY954

• NA Trzaskalsk, B Vulesevic, MA Nguyen, N Jeraj, E Fadzeyeva, NM Morrow, CA Locatelli, N Travis, AA Hanson, JR Nunes, C O'Dwyer, JN Van der Ve, I Lorenzen-S, R Seymour, SM Pulente, AC Clément, AM Crawley, RL Jacobs, MA Doyle, CL Cooper, KH Kim, MD Fullerton, EE Mulvihill Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, glucose production, and its absence alters liver disease progression JCI Insight, 2023-01-24;0(0):. 2023-01-24 [PMID: 36472923] (Mouse)
• R Kamakura, GS Raza, A Prasannan, J Walkowiak, KH Herzig Dipeptidyl peptidase 4 and GLP-1 interplay in STC-1 and GLUTag cell lines Peptides, 2020-09-28;0(0):170419. 2020-09-28 [PMID: 32998057] (Mouse)
• LL Baggio, EM Varin, JA Koehler, X Cao, Y Lokhnygina, SR Stevens, RR Holman, DJ Drucker Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans Nat Commun, 2020-07-28;11(1):3766. 2020-07-28 [PMID: 32724076] (Mouse)
• S Saussentha, M Ouni, C Baumeier, K Schwerbel, P Gottmann, S Christmann, T Laeger, A Schürmann Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein J. Nutr. Biochem., 2018-10-13;63(0):109-116. 2018-10-13 [PMID: 30359860] (Mouse)
• M Rödiger, MW Werno, I Wilhelmi, C Baumeier, D Hesse, N Wettschure, S Offermanns, K Song, M Krau beta , A Schürmann Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes Mol Metab, 2017-11-22;0(0):. 2017-11-22 [PMID: 29203237] (Mouse)
• C Baumeier, L Schlüter, S Saussentha, T Laeger, M Rödiger, SA Alaze, L Fritsche, HU Häring, N Stefan, A Fritsche, RW Schwenk, A Schürmann Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease Mol Metab, 2017-08-04;6(10):1254-1263. 2017-08-04 [PMID: 29031724] (Mouse)
• Barreira da Silva R, Laird M, Yatim N, Fiette L, Ingersoll M, Albert M Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nat Immunol, 2015-06-15;16(8):850-8. 2015-06-15 [PMID: 26075911] (Mouse)
• Pang , Zhengda, Nakagami , Hironori, Osako , Mariana, Koriyama , Hiroshi, Nakagami , Futoshi, Tomioka , Hideki, Shimamura , Munehisa, Kurinami , Hitomi, Takami , Yoichi, Morishita , Ryuichi, Rakugi , Hiromi Therapeutic vaccine against DPP4 improves glucose metabolism in mice. Proc Natl Acad Sci U S A, 2014-03-17;111(13):E1256-63. 2014-03-17 [PMID: 24639549] (Mouse)

FAQs for DPPIV/CD26 (DY954). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Dpp4