MIS RII/AMHR2 Antibody (MIG7)

Product Discontinued

MIS RII/AMHR2 Antibody (MIG7) Summary

• Immunogen: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with peptide 117-130 (NANYSHLPPPGSPG) conjugated with hsp70.
• Specificity: Human cells bearing MISR, extracellular domain.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: AMHR2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein G purified

Alternate Names for MIS RII/AMHR2 Antibody (MIG7)

• AMH type II receptor
• AMHR2
• AMHREC 2.7.11.30
• AMHRII
• C14
• MIS RII
• MISR2
• MISRII
• MISRIIMIS type II receptor
• MRII
• Muellerian hormone type II receptor
• Muellerian hormone type-2 receptor
• Mullerian hormone receptor, type II
• Mullerian inhibiting substance type II receptor

Background

AMHR2 is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins that is expressed in fetal and adult gonads of both sexes. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. A number of allelic variants of AMHR2 are associated with persistent mullerian duct syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MIS RII/AMHR2 Antibody (NBP1-05491)(1)

Publication using NBP1-05491

• Liuzzi F, Taggi M, De Carlini S, La Marca A Anti-Müllerian Hormone promotes human osteoblast differentiation and calcification by modulating osteogenic gene expression Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023-12-01 [PMID: 37913790] (Western Blot, Human)

Bioinformatics

• Gene Symbol: AMHR2
• Entrez:
  • 269(Human)
  • 29530(Rat)
• Uniprot:
  • Q16671()