Methionine Aminopeptidase 1/METAP1 Antibody (405419) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB
• Clone: 405419
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Methionine Aminopeptidase 1/METAP1 Antibody (405419) [Alexa Fluor® 594] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Methionine Aminopeptidase 1/METAP1
  His52-Phe386
  Accession # P53582
• Specificity: Detects human Methionine Aminopeptidase 1/METAP1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human Methionine Aminopeptidase 2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Methionine Aminopeptidase 1/METAP1 Antibody (405419) [Alexa Fluor® 594]

• DKFZp781C0419
• EC 3.4.11.18
• KIAA0094MAP 1
• MAP1
• MAP1A
• MetAP 1
• MetAP1
• MetAP1A
• Methionine Aminopeptidase 1
• methionyl aminopeptidase 1
• Peptidase M 1

Background

The human METAP1 gene encodes Methionine Aminopeptidase 1, a member of the M24 family of metalloproteases. METAPs catalyze the removal of the initiator methionine residue from nascent peptides (1) and are essential for cell growth (2). Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs (3). The amino acid sequence of human METAP1 is 99%, 98%, 95% and 64% identical to that of chimpanzee, rat/mouse, chicken and fruit fly.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.