MEL-18 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

MEL-18 Antibody [DyLight 650] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 125 and 175 of human DNA-binding Protein Mel-18 using the numbering given in entry NP_009075.1 (GeneID 7703).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PCGF2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for MEL-18 Antibody [DyLight 650]

• MEL-18
• polycomb group ring finger 2
• polycomb group RING finger protein 2
• RING finger protein 110DNA-binding protein Mel-18
• RNF110MEL18
• Zinc finger protein 144
• ZNF144MGC10545

Background

MEL-18 is a transcriptional repressor that binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel18 has tumor suppressor activity and may play a role in cell proliferation and/or neural cell development. It regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PCGF2