Lyp/PTPN22 Antibody (340113) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 340113
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Lyp/PTPN22 Antibody (340113) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Lyp
  Ser306-Ser684
  Accession # Q9Y2R2
• Specificity: Detects human Lyp in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Lyp/PTPN22 Antibody (340113) [Alexa Fluor® 750]

• EC 3.1.3.48
• Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
• Lymphoid phosphatase
• lymphoid-specific protein tyrosine phosphatase
• Lyp
• Lyp1
• Lyp2
• LyPTP
• PEP
• PEST-domain phosphatase
• protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
• protein tyrosine phosphatase, non-receptor type 8
• PTPN22
• PTPN8 (former)
• PTPN8LYP1
• tyrosine-protein phosphatase non-receptor type 22

Background

Lymphoid phosphatase (Lyp), also called LyPTP, Protein Tyrosine Phosphatase, Nonreceptor-type 22 (PTPN22), and PEST-domain Phosphatase (PEP), dephosphorylates tyrosine residues in proteins. Found primarily in bone marrow and lymphoid cell lines, an R620W gain-of-function mutation in Lyp has been associated with susceptibility to autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus erythematosus. Mature PEP knockout mice have an excess of CD8 positive T cells and an exaggerated antigen-induced proliferative response.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.