LIR-8/CD85c/LILRB5 Antibody (395239)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
395239
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

LIR-8/CD85c/LILRB5 Antibody (395239) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human LILRB5/CD85c/LIR-8 isoform 1
Arg18-His456
Accession # O75023
Specificity
Detects human LILRB5/CD85c/LIR-8 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) ILT1, 2, 3, 4, 5, rhLIR-6, or rhILT11/LILRA5 is observed. In Western blots, less than 5% cross-reactivity with rhILT2, 3, 5, rhLIR-6 or rhILT11/LILRA5 is observed, and no cross-reactivity with rhILT1, 4, or 6.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
LILRB5
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LIR-8/CD85c/LILRB5 Antibody (395239)

  • CD85 antigen-like family member C
  • CD85c antigen
  • CD85c
  • Leukocyte immunoglobulin-like receptor 8
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
  • LILRB5
  • LIR8
  • LIR-8
  • LIR8CD85C
  • LIR-8leukocyte immunoglobulin-like receptor subfamily B member 5
  • member 5

Background

Human LIR-8 (leukocyte immunoglobulin-like receptor 8; also CD85c and LILRB5) is a 567 amino acid (aa) member of the LIR family of receptors. It is a type I transmembrane protein that is expressed on NK cells. LIR-8 has a 435 aa extracellular domain with four C2-type Ig-like domains (aa 24‑458), and a 111 aa cytoplasmic tail that contains two ITIM motifs. Phosphorylation of Tyr in an ITIM motif recruits SHP-1, which is subsequently activated and impacts related signaling pathways. The ligand for, and function of, LIR-8 are unreported. LIR-8 has two potential splice forms. One shows a 53 aa cytoplasmic insert between Arg542 and Ala543. The second shows a deletion of 100 aa between Gly119 and Gly219 that impacts the second C2-type Ig-like domain. There is no rodent ortholog.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LILRB5
Entrez
Uniprot