LINGO-2 Antibody [Unconjugated]

Product Discontinued

LINGO-2 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LINGO-2
  Cys28-Leu542
  Accession # Q7L985
• Specificity: Detects human LINGO-2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human
  LINGO‑1 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: LINGO2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LINGO-2 Antibody [Unconjugated]

• LERN3
• LERN3FLJ31810
• leucine rich repeat and Ig domain containing 2
• leucine-rich repeat and immunoglobulin-like domain-containing nogoreceptor-interacting protein 2
• Leucine-rich repeat neuronal protein 3
• Leucine-rich repeat neuronal protein 6C
• LINGO2
• LINGO-2
• LRRN6C
• LRRN6Cleucine rich repeat neuronal 6C

Background

LINGO-2, also known as Leucine-rich repeat neuronal 6C (LRRN6C), is a type I transmembrane protein in the neuronal leucine-rich repeat family. These proteins have a signal peptide, 12 extracellular leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich sequences, an immunoglobulin-like domain, a transmembrane domain and a short cytoplasmic tail. Human LINGO-2 is a 606 amino acid protein with unknown functions. It is highly conserved, sharing 99% and 98% aa sequence identity with canine and mouse LINGO-2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LINGO-2 Antibody (AF3679)(1)

Publication using AF3679

• NM Belle, Y Ji, K Herbine, Y Wei, J Park, K Zullo, LY Hung, S Srivatsa, T Young, T Oniskey, C Pastore, W Nieves, M Somsouk, DR Herbert TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths Nat Commun, 2019-09-27;10(1):4408. 2019-09-27 [PMID: 31562318] (IHC-P, Human)

Bioinformatics

• Gene Symbol: LINGO2
• Uniprot:
  • Q7L985()