Lgi1 Antibody

Images

 
Western Blot: Lgi1 Antibody [NBP1-77320] - HeLa cell lysate with LGI1 antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: Lgi1 Antibody [NBP1-77320] - Human brain tissue using LGI1 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Lgi1 Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from near the center of human LGI1. The immunogen is located within amino acids 370 - 420 of LGI1.
Specificity
This LGI1 antibody is predicted to be specific to LGI1 and not recognize other LGI proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LGI1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence
Control Peptide
Lgi1 Peptide (NBP1-77320PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Lgi1 Antibody

  • ADLTE
  • ADPAEF
  • ADPEAF
  • BB130740
  • epilepsy, partial
  • Epitempin
  • Epitempin-1
  • EPT
  • EPTleucine-rich glioma-inactivated protein 1
  • ETL1
  • ETL1epitempin-1
  • IB1099
  • leucine-rich, glioma inactivated 1
  • LGI1

Background

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist; this LGI1 antibody will recognize only the longer form. This LGI1 antibody is predicted to be specific to LGI1 and not recognize other LGI proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LGI1
Entrez
Uniprot