LAX1 Antibody

Product Discontinued

LAX1 Antibody Summary

• Immunogen: Peptide with sequence NLTPSAHCINVRAS corresponding to internal region according to NP_060243.2, NP_001129662.1.
• Epitope: NLTPSAHCINVRAS
• Specificity: This antibody is expected to recognize both reported isoforms (NP_060243.2; NP_001129662.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: LAX1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in lysates of peripheral blood mononucleocytes and of cell lines HeLa and MOLT4 gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for LAX1 Antibody

• LAT-like membrane associated protein
• LAX1
• LAXFLJ20340
• Linker for activation of X cells
• lymphocyte transmembrane adapter 1
• lymphocyte transmembrane adaptor 1
• Membrane-associated adapter protein LAX

Background

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LAX1 Antibody (NBP1-52145)(1)

Publication using NBP1-52145

• Zhu M, Janssen E, Leung K, Zhang W. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. J Biol Chem 2002-11-29 [PMID: 12359715]

Bioinformatics

• Gene Symbol: LAX1
• Entrez:
  • 54900(Human)
• Uniprot:
  • NP_060243.2(Human)